Mubritinib Targets the Electron Transport Chain Complex I and Reveals the Landscape of Mitochondrial Vulnerability in Acute Myeloid Leukemia

Irene Baccelli, Yves Gareau, Bernhard Lehnertz, Gingras Stephane, Jean-Francois Spinella, Alexandre Beautrait, Sophie Corneau, Nadine Mayotte, Isabel Boivin, Simon Girard, Tara MacRae, Melanie Frechette, Koryne Leveille, Jana Krosl, Clarisse Thiollier, Evgeny Kanshin, Thierry Bertomeu, Jasmin Coulombe-Huntington, Corinne St-Denis, Marie-Eve Bordeleau, Geneviève Boucher, P Philippe Roux, Sébastien Lemieux, Mike Tyers, Pierre Thibault, Anne Marinier, Josée Hébert, Guy Sauvageau

Abstract

BACKGROUND

Type

Journal article

Publication

Blood

Sébastien Lemieux

Principal Investigator

Principal Investigator, Functional and Structural Bioinformatics Research Unit, IRIC | Scientific direction of the Bioinformatics platform | Associate Professor, Department of Biochemistry and Molecular Medicine, Université de Montréal