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Identification of Acute Myeloid Leukemia Cell Surface Therapeutic Targets Using Single Cell RNA Sequencing Supported By Surface Proteomics
Acute myeloid leukemia (AML) comprises diverse genomic subgroups and remains hard to treat in most patients. Despite breakthroughs in …
Véronique Lisi
,
Banafsheh Khakipoor
,
Azer Farah
,
Louis Thérêt
,
Jean-Francois Spinella
,
Jalila Chagraoui
,
Ossama Moujaber
,
Laure Mallinger
,
Isabel Boivin
,
Nadine Mayotte
,
Azadeh Hajmirza
,
Éric Bonneil
,
Frnaçois Béliveau
,
Albert Feghali
,
Geneviève Boucher
,
Patrick Gendron
,
Frederic Barabe
,
Sébastien Lemieux
,
Guillaume Richard-Carpentier
,
Josée Hébert
,
Philippe Roux
,
Guy Sauvageau
,
Vincent-Philippe Lavallée
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DOI
Unmutated tumor antigens are abundant and contribute to tumor control in melanoma
Recognition of MHC-I-associated tumor antigens (TAs) by CD8+ T cells is central to antitumor immunity. Owing to the elevated tumor …
Anca Apavaloaei
,
Qingchuan Zhao
,
Leslie Hesnard
,
Krystel Vincent
,
Marie-Pierre Hardy
,
Chantal Durette
,
Joël Lanoix
,
Jean-Philippe Laverdure
,
Jean-David Larouche
,
al-mavi-ruiz
,
Gregory Ehx
,
Sébastien Lemieux
,
Pierre Thibault
,
Claude Perreault
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DOI
Identification of Novel Cell Surface Therapeutic Targets for KMT2A-Rearranged Acute Myeloid Leukemia
Acute myeloid leukemia (AML) is a highly heterogeneous disease that represents 80% of adult leukemias and is characterized by …
Louis Thérêt
,
Marie-Eve Bordeleau
,
Azadeh Hajmirza
,
Arnaud Metois
,
Ossama Moujaber
,
Éric Audemard
,
Jean-Francois Spinella
,
Jalila Chagraoui
,
Léo Aubert
,
Azer Farah
,
Véronique Lisi
,
Éric Bonneil
,
Isabel Boivin
,
Nadine Mayotte
,
Tara MacRae
,
Pierre Thibault
,
Sébastien Lemieux
,
Vincent-Philippe Lavallée
,
Josée Hébert
,
Guy Sauvageau
,
Philippe Roux
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DOI
IL1R1 Expression Predicts the Benefit from Allogeneic Hematopoietic Stem Cell Transplantation in Patients with Acute Myeloid Leukemia and Intermediate-Risk Cytogenetics
Acute myeloid leukemia (AML) is a heterogeneous hematological malignancy with variable clinical outcomes depending on baseline patient …
Guillaume Richard-Carpentier
,
Francois Beliveau
,
Sandrine Lacoste
,
Jean-Francois Spinella
,
Michael Vladovsky
,
Patrick Gendron
,
Sébastien Lemieux
,
Vincent-Philippe Lavallée
,
Guy Sauvageau
,
Josée Hébert
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DOI
Targeting PLZF Enhances Glucocorticoid Sensitivity in Acute Myeloid Leukemia
Glucocorticoids (GCs) are Glucocorticoid Receptor (GR) agonists that are extensively used in clinic, from management of autoimmune and …
Azadeh Hajmirza
,
Laura Simon
,
Jalila Chagraoui
,
Nadine Mayotte
,
Jean-Francois Spinella
,
Tara MacRae
,
Bernhard Lehnertz
,
Thierry Bertomeu
,
Jasmin Coulombe-Huntington
,
Geneviève Boucher
,
Sébastien Lemieux
,
Mike Tyers
,
Josée Hébert
,
Guy Sauvageau
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DOI
ECTmatch - Optimizing Small-Scale Cord Blood Banking Through HLA Analysis
Cord blood (CB) banks have had to rely on large inventories of CB units to try to serve the largest possible proportion of the …
Maude Dumont-Lagacé
,
Albert Feghaly
,
Gabrielle Thauvette
,
Marie-Christine Meunier
,
William Lemieux
,
Diane Fournier
,
Lucie Richard
,
Sébastien Lemieux
,
Guy Sauvageau
,
Sandra Cohen
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DOI
BamQuery - A new proteogenomic tool to explore the immunopeptidome and validate tumor‐specific antigens
MHC class I–associated peptides (MAPs), collectively referred to as the immunopeptidome, have a pivotal role in cancer …
Virginia Maria Ruiz
,
Anca Apavaloaei
,
Qingchuan Zhao
,
Marie-Pierre Hardy
,
Sébastien Lemieux
,
Claude Perreault
,
Gregory Ehx
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DOI
Exploring glucocorticoid sensitivity modulators in human acute myeloid leukemia
Azadeh Hajmirza
,
Laura Simon
,
Jean-Francois Spinella
,
Tara MacRae
,
Bernhard Lehnertz
,
Jalila Chagraoui
,
Nadine Mayotte
,
Thierry Bertomeu
,
Jasmin Coulombe-Huntington
,
Geneviève Boucher
,
Albert Feghaly
,
Marie-Eve Bordeleau
,
Sébastien Lemieux
,
Mike Tyers
,
Josée Hébert
,
Guy Sauvageau
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DOI
Single UM171-Expanded Cord Blood Transplants Support Robust T-Cell Reconstitution with Low Rates of Severe Infections
Maude Dumont-Lagacé
,
Qi Li
,
Mégane Tanguay
,
Jalila Chagraoui
,
Tibila Kientega
,
B. Guillaume Cardin
,
Ann Brasey
,
Assya Trofimov
,
Cédric Carli
,
Imran Ahmad
,
Nadia Bambace
,
Léa Bernard
,
L. Thomas Kiss
,
Jean Roy
,
Denis-Claude Roy
,
Sébastien Lemieux
,
Claude Perreault
,
Francis Rodier
,
Frédéric Simon Dufresne
,
Lambert Busque
,
Silvy Lachance
,
Guy Sauvageau
,
Sandra Cohen
,
Jean-Sébastien Delisle
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DOI
Surface proteomics reveals novel potentiel AML antigens for immunitherapeutic targeting
Compared to solid tumors, antibody-based immunotherapy is underexploited in acute myeloid leukemia (AML), likely due to the limited …
Marie-Eve Bordeleau
,
Louis Thérêt
,
Éric Audemard
,
Jean-Francois Spinella
,
Léo Aubert
,
Isabel Boivin
,
Éric Bonneil
,
Pierre Thibault
,
Sébastien Lemieux
,
Vincent-Philippe Lavallée
,
Josée Hébert
,
Philippe Roux
,
Guy Sauvageau
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