S. Lemieux

Latest

• Atypical acute myeloid leukemia-specific transcripts generate shared and immunogenic MHC class-I-associated epitopes
• CAMAP: Artificial neural networks unveil the role of codon arrangement in modulating MHC-I peptides presentation
• Most non-canonical proteins uniquely populate the proteome or immunopeptidome
• p16INK4a Regulates Cellular Senescence in PD-1-Expressing Human T Cells
• UM171-Expanded Cord Blood Transplants Support Robust T Cell Reconstitution with Low Rates of Severe Infections
• Vesicular trafficking is a key determinant of the statin response in acute myeloid leukemia
• Factorized embeddings learns rich and biologically meaningful embedding spaces using factorized tensor decomposition
• Genetic characterization of ABT-199 sensitivity in human AML
• Hematopoietic stem cell transplantation using single UM171-expanded cord blood: a single-arm, phase 1-2 safety and feasibility study
• High frequency of germline RUNX1 mutations in patients with RUNX1-mutated AML
• MAPDP: A Cloud-Based Computational Platform for Immunopeptidomics Analyses
• Proteogenomics Uncovers a Vast Repertoire of Shared Tumor-Specific Antigens in Ovarian Cancer
• STRIPAK regulates Slik localization to control mitotic morphogenesis and epithelial integrity
• Widespread and tissue-specific expression of endogenous retroelements in human somatic tissues
• Complex karyotype AML displays G2/M signature and hypersensitivity to PLK1 inhibition
• Correction: High expression of HMGA2 independently predicts poor clinical outcomes in acute myeloid leukemia
• Enhancing the drug discovery process: Bayesian inference for the analysis and comparison of dose-response experiments
• Hepatic leukemia factor is a novel leukemic stem cell regulator in DNMT3A, NPM1, and FLT3-ITD triple-mutated AML
• Mubritinib Targets the Electron Transport Chain Complex I and Reveals the Landscape of OXPHOS Dependency in Acute Myeloid Leukemia
• Qualitative Changes in Cortical Thymic Epithelial Cells Drive Postpartum Thymic Regeneration
• Targeted variant detection using unaligned RNA-Seq reads
• Noncoding regions are the main source of targetable tumor-specific antigens
• Transcriptomic landscape of acute promyelocytic leukemia reveals aberrant surface expression of the platelet aggregation agonist Podoplanin
• A novel approach for the identification of efficient combination therapies in primary human acute myeloid leukemia specimens
• Chemogenomic Landscape of RUNX1-mutated AML Reveals Importance of RUNX1 Allele Dosage in Genetics and Glucocorticoid Sensitivity
• Detection of Quiescent Radioresistant Epithelial Progenitors in the Adult Thymus
• MiSTIC, an integrated platform for the analysis of heterogeneity in large tumour transcriptome datasets
• Chemo-genomic interrogation of CEBPA mutated AML reveals recurrent CSF3R mutations and subgroup sensitivity to JAK inhibitors
• Expression of immunoproteasome genes is regulated by cell-intrinsic and -extrinsic factors in human cancers
• Global proteogenomic analysis of human MHC class I-associated peptides derived from non-canonical reading frames
• GPR56 identifies primary human acute myeloid leukemia cells with high repopulating potential in vivo
• Identification of MYC mutations in acute myeloid leukemias with NUP98-NSD1 translocations
• MHC class I-associated peptides derive from selective regions of the human genome
• Proteogenomic-based discovery of minor histocompatibility antigens with suitable features for immunotherapy of hematologic cancers
• pyGeno: A Python package for precision medicine and proteogenomics
• RNA-sequencing analysis of core binding factor AML identifies recurrent ZBTB7A mutations and defines RUNX1-CBFA2T3 fusion signature
• Transcriptome analysis of G protein-coupled receptors in distinct genetic subgroups of acute myeloid leukemia: identification of potential disease-specific targets
• Differential Features of AIRE-Induced and AIRE-Independent Promiscuous Gene Expression in Thymic Epithelial Cells
• EVI1-rearranged acute myeloid leukemias are characterized by distinct molecular alterations
• The NMR structure of the II-III-VI three-way junction from the Neurospora VS ribozyme reveals a critical tertiary interaction and provides new insights into the global ribozyme structure
• The transcriptomic landscape and directed chemical interrogation of MLL-rearranged acute myeloid leukemias
• A functional screen reveals an extensive layer of transcriptional and splicing control underlying RAS/MAPK signaling in Drosophila
• Epigenetic regulation of GATA2 and its impact on normal karyotype acute myeloid leukemia
• Identification of small molecules that support human leukemia stem cell activity ex vivo
• Impact of genomic polymorphisms on the repertoire of human MHC class I-associated peptides
• SCL, LMO1 and Notch1 reprogram thymocytes into self-renewing cells
• Correction of spatial bias in oligonucleotide array data
• Genetic interaction between Kit and Scl
• Harnessing virtual machines to simplify next-generation DNA sequencing analysis
• Phosphoproteome dynamics reveal novel ERK1/2 MAP kinase substrates with broad spectrum of functions
• RNA-Seq reveals spliceosome and proteasome genes as most consistent transcripts in human cancer cells
• The TGF-β-Smad3 pathway inhibits CD28-dependent cell growth and proliferation of CD4 T cells
• Transcriptome sequencing of neonatal thymic epithelial cells
• A key role for EZH2 and associated genes in mouse and human adult T-cell acute leukemia
• Helix-length compensation studies reveal the adaptability of the VS ribozyme architecture
• MHC I-associated peptides preferentially derive from transcripts bearing miRNA response elements
• Occurrence and detection of phosphopeptide isomers in large-scale phosphoproteomics experiments
• ProteoConnections: a bioinformatics platform to facilitate proteome and phosphoproteome analyses
• The MHC I immunopeptidome conveys to the cell surface an integrative view of cellular regulation
• A comprehensive map of the mTOR signaling network
• Deletion of immunoproteasome subunits imprints on the transcriptome and has a broad impact on peptides presented by major histocompatibility complex I molecules
• Depletion of the cullin Cdc53p induces morphogenetic changes in Candida albicans
• Structural and electrostatic characterization of pariacoto virus: implications for viral assembly
• The phagosomal proteome in interferon-gamma-activated macrophages
• Genomewide location analysis of Candida albicans Upc2p, a regulator of sterol metabolism and azole drug resistance
• Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus
• Quantitative expression profiling guided by common retroviral insertion sites reveals novel and cell type specific cancer genes in leukemia
• Role of SLV in SLI substrate recognition by the Neurospora VS ribozyme
• The MHC class I peptide repertoire is molded by the transcriptome
• Essential gene identification and drug target prioritization in Aspergillus fumigatus
• Functional calcitonin gene-related peptide receptors are formed by the asymmetric assembly of a calcitonin receptor-like receptor homo-oligomer and a monomer of receptor activity-modifying protein-1
• Genome-wide fitness test and mechanism-of-action studies of inhibitory compounds in Candida albicans
• Automated extraction and classification of RNA tertiary structure cyclic motifs
• Probe-level linear model fitting and mixture modeling results in high accuracy detection of differential gene expression
• Large-scale essential gene identification in Candida albicans and applications to antifungal drug discovery
• RNA canonical and non-canonical base pairing types: a recognition method and complete repertoire
• Quantitative analysis of nucleic acid three-dimensional structures
• Function of hexameric RNA in packaging of bacteriophage phi 29 DNA in vitro
• Modeling active RNA structures using the intersection of conformational space: application to the lead-activated ribozyme