M. P. Hardy

Récents

• Atypical acute myeloid leukemia-specific transcripts generate shared and immunogenic MHC class-I-associated epitopes
• Most non-canonical proteins uniquely populate the proteome or immunopeptidome
• Noncoding regions are the main source of targetable tumor-specific antigens
• Global proteogenomic analysis of human MHC class I-associated peptides derived from non-canonical reading frames
• Impact of genomic polymorphisms on the repertoire of human MHC class I-associated peptides
• The TGF-β-Smad3 pathway inhibits CD28-dependent cell growth and proliferation of CD4 T cells
• The MHC I immunopeptidome conveys to the cell surface an integrative view of cellular regulation
• Deletion of immunoproteasome subunits imprints on the transcriptome and has a broad impact on peptides presented by major histocompatibility complex I molecules
• The MHC class I peptide repertoire is molded by the transcriptome