J. Hebert

Récents

• Atypical acute myeloid leukemia-specific transcripts generate shared and immunogenic MHC class-I-associated epitopes
• Vesicular trafficking is a key determinant of the statin response in acute myeloid leukemia
• Genetic characterization of ABT-199 sensitivity in human AML
• High frequency of germline RUNX1 mutations in patients with RUNX1-mutated AML
• Complex karyotype AML displays G2/M signature and hypersensitivity to PLK1 inhibition
• Correction: High expression of HMGA2 independently predicts poor clinical outcomes in acute myeloid leukemia
• Hepatic leukemia factor is a novel leukemic stem cell regulator in DNMT3A, NPM1, and FLT3-ITD triple-mutated AML
• Mubritinib Targets the Electron Transport Chain Complex I and Reveals the Landscape of OXPHOS Dependency in Acute Myeloid Leukemia
• Targeted variant detection using unaligned RNA-Seq reads
• Transcriptomic landscape of acute promyelocytic leukemia reveals aberrant surface expression of the platelet aggregation agonist Podoplanin
• A novel approach for the identification of efficient combination therapies in primary human acute myeloid leukemia specimens
• Chemogenomic Landscape of RUNX1-mutated AML Reveals Importance of RUNX1 Allele Dosage in Genetics and Glucocorticoid Sensitivity
• MiSTIC, an integrated platform for the analysis of heterogeneity in large tumour transcriptome datasets
• Chemo-genomic interrogation of CEBPA mutated AML reveals recurrent CSF3R mutations and subgroup sensitivity to JAK inhibitors
• Expression of immunoproteasome genes is regulated by cell-intrinsic and -extrinsic factors in human cancers
• GPR56 identifies primary human acute myeloid leukemia cells with high repopulating potential in vivo
• Identification of MYC mutations in acute myeloid leukemias with NUP98-NSD1 translocations
• RNA-sequencing analysis of core binding factor AML identifies recurrent ZBTB7A mutations and defines RUNX1-CBFA2T3 fusion signature
• Transcriptome analysis of G protein-coupled receptors in distinct genetic subgroups of acute myeloid leukemia: identification of potential disease-specific targets
• EVI1-rearranged acute myeloid leukemias are characterized by distinct molecular alterations
• The transcriptomic landscape and directed chemical interrogation of MLL-rearranged acute myeloid leukemias
• Epigenetic regulation of GATA2 and its impact on normal karyotype acute myeloid leukemia
• Identification of small molecules that support human leukemia stem cell activity ex vivo
• SCL, LMO1 and Notch1 reprogram thymocytes into self-renewing cells
• RNA-Seq reveals spliceosome and proteasome genes as most consistent transcripts in human cancer cells
• A key role for EZH2 and associated genes in mouse and human adult T-cell acute leukemia
• Quantitative expression profiling guided by common retroviral insertion sites reveals novel and cell type specific cancer genes in leukemia