G. Boucher

Récents

• Vesicular trafficking is a key determinant of the statin response in acute myeloid leukemia
• Genetic characterization of ABT-199 sensitivity in human AML
• High frequency of germline RUNX1 mutations in patients with RUNX1-mutated AML
• Mubritinib Targets the Electron Transport Chain Complex I and Reveals the Landscape of OXPHOS Dependency in Acute Myeloid Leukemia
• A novel approach for the identification of efficient combination therapies in primary human acute myeloid leukemia specimens
• Chemogenomic Landscape of RUNX1-mutated AML Reveals Importance of RUNX1 Allele Dosage in Genetics and Glucocorticoid Sensitivity
• MiSTIC, an integrated platform for the analysis of heterogeneity in large tumour transcriptome datasets
• Chemo-genomic interrogation of CEBPA mutated AML reveals recurrent CSF3R mutations and subgroup sensitivity to JAK inhibitors
• Expression of immunoproteasome genes is regulated by cell-intrinsic and -extrinsic factors in human cancers
• GPR56 identifies primary human acute myeloid leukemia cells with high repopulating potential in vivo
• Identification of MYC mutations in acute myeloid leukemias with NUP98-NSD1 translocations
• RNA-sequencing analysis of core binding factor AML identifies recurrent ZBTB7A mutations and defines RUNX1-CBFA2T3 fusion signature
• The transcriptomic landscape and directed chemical interrogation of MLL-rearranged acute myeloid leukemias
• Identification of small molecules that support human leukemia stem cell activity ex vivo
• Impact of genomic polymorphisms on the repertoire of human MHC class I-associated peptides
• The TGF-β-Smad3 pathway inhibits CD28-dependent cell growth and proliferation of CD4 T cells
• A key role for EZH2 and associated genes in mouse and human adult T-cell acute leukemia